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High iron levels are a risk factor for type 2 diabetes mellitus (T2DM) and impacts the cardinal features: such as increased insulin resistance, decreased insulin secretion and elevated hepatic gluconeogenesis

Nrf2 depletion has been shown to cause renal oxidative and nitrosative stress in hyperglycemia-induced STZ mice (Yoh et al., 2008)

Maalouf M, Sullivan PG, Davis L, Kim DY, Rho JM

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Reducing oxidative stress may help prevent chronic diseases and promote overall well-being